Determination of Pain Management Drugs using Automated Disposable Pipette Extraction and LC-MS/MS


App Note 6/2011

This study focuses on the automated extraction of small sample volumes combined with LC-MS/MS analysis providing high throughput analysis of common pain management drugs. Using a GERSTEL MultiPurpose Sampler (MPS), DPX extractions of hydrolyzed urine were performed, using a reversed phase sorbent with a proprietary salt additive (DPX-RP-S). The resulting eluents from the automated DPX extractions were introduced into an Agilent 6460 LC-MS/MS instrument.