America’s Center Convention Complex
701 Convention Plaza
St. Louis, MO 63101
What to Expect:
GERSTEL will be at the 63rd ASMS Conference on Mass Spectrometry and Allied Topics at Booth 94. We will also be presenting our poster on June 3rd from 10:30 am-2:30 pm titled, "Automating Liquid-Liquid Extractions using an X-Y-Z Coordinate Autosampler for LC/MS/MS Analyses."
The poster is based on the following:
Liquid-liquid extractions have long been performed manually and are used to extract and concentrate analytes from aqueous matrices. Inclusion of liquid-liquid extraction in many official methods attests to the wide acceptance of the technique. Following solvent extraction it is also common to include an evaporation and reconstitution step to improve detection limits or exchange solvents for compatibility with subsequent chromatographic separations. Modern analytical labs are looking to automation to help reduce solvent usage and increase sample throughput while ensuring the high quality of the resulting data.
A single X-Y-Z coordinate autosampler commonly used for sample introduction in GC/MS or LC/MS/MS can be used to perform a wide variety of sample preparation techniques using a single instrument and controlling software. The sampler can be configured as part of a GC/MS or LC/MS/MS system or can be configured as a bench-top workstation and can also include a six position evaporation station.
In this report, the automation of liquid-liquid extractions by the autosampler is discussed. Examination of a new, automated centrifugation option that allows samples to be rapidly and effectively centrifuged using speeds of up to 4500rpm to efficiently separate liquid phases is described. Automated liquid-liquid extraction methods for a variety of analytes from different matrices are examined. Replicates were prepared and analyzed, and the resulting precision data show %RSDs typically between 0.4-1%.
Automation of liquid-liquid extraction procedures coupled with LC/MS/MS analyses.
For more information regarding this event, visit their website.